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BTE 004-09-02 detects Pregnancy-associated plasma protein A (PAPP-A) from human samples. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A.
BTE 004-09-02 has been successfully used in ELISA, Western blotting and Immunohistochemistry procedures. In sandwich ELISA the optimal combination is BTE 004-09-02 used as coating antibody and biotinylated ABS 006-24-02 used as detection antibody. BTE 004-09-02 can also be used as detection antibody in sandwich ELISA in combination with a polyclonal antibody towards PAPP-A in coat. BTE 004-09-02 detect both reduced and unreduced PAPP-A in Western Blotting, though reaction to unreduced is less than that of ABS 006-01-02 and ABS 006-24-02.
The epitope of BTE 004-09-02 is different from ABS 006-01-02 and ABS 006-24-02. The epitope is located on the PAPP-A subunit of the heterotetramer.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterottetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down's syndrome (trisomy 21).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; IGF-dependent IGFBP-4 protease; IGFBP-4 ase; insulin-like growth factor-dependent IGF binding protein-4 protease; Insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPP A; PAPP-A; Pappalysin; Pappalysin-1; pregnacy-associated plasma protein A; Pregnancy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1; RP11-45A16.1
基因别名: ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA; PAPPA1
UniProt ID: (Human) Q13219
Entrez Gene ID: (Human) 5069